解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(00)80043-4
更新日期:1996-02-01 00:00:00
abstract::Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80053-7
更新日期:1996-02-01 00:00:00
abstract::Voltage-activated potassium (Kv) channels from mammalian brain are hetero-oligomers containing alpha and beta subunits. Coexpression of Kv1 alpha and Kv beta 1 subunits confers rapid A-type inactivation on noninactivating potassium channels (delayed rectifiers) in expression systems in vitro. We have delineated a Kv1....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80063-x
更新日期:1996-02-01 00:00:00
abstract::The M current regulates neuronal excitability, with its amplitude resulting from high open probability modal M channel behavior. The M current is affected by changing intracellular calcium levels. It is proposed that internal calcium acts by regulating M channel modal gating. Intracellular application of a preactivate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80033-1
更新日期:1996-01-01 00:00:00
abstract::Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90005-5
更新日期:1995-12-01 00:00:00
abstract::The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin prep...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90015-2
更新日期:1995-12-01 00:00:00
abstract::Simultaneous somatic and dendritic recordings were made from the same neocortical layer V pyramidal neuron, and current injection via the dendritic recording pipette was used to simulate the voltage change that occurs during an EPSP. At the soma, these simulated EPSPs increased nonlinearly with the amplitude of the de...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90095-0
更新日期:1995-11-01 00:00:00
abstract::To study the effect of cell type-restricted hamster PrP expression on susceptibility to the hamster scrapie agent, we generated transgenic mice using a 1 kb hamster cDNA clone containing the 0.76 kb HPrP open reading frame under control of the neuron-specific enolase promoter. In these mice, expression of HPrP was det...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90105-1
更新日期:1995-11-01 00:00:00
abstract::The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90172-8
更新日期:1995-10-01 00:00:00
abstract::Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90182-5
更新日期:1995-10-01 00:00:00
abstract::The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90149-3
更新日期:1995-09-01 00:00:00
abstract::Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90159-0
更新日期:1995-09-01 00:00:00
abstract::About two-thirds of the antibodies to the nicotinic acetylcholine (ACh) receptor in patients with the autoimmune disease myasthenia gravis bind to the main immunogenic region (MIR). This is small, well-defined region on each of the two alpha subunits, containing residues 67-76 (alpha 67-76). By determining the structu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90037-3
更新日期:1995-08-01 00:00:00
abstract::A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90040-3
更新日期:1995-08-01 00:00:00
abstract::The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90073-x
更新日期:1995-07-01 00:00:00
abstract::Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90064-0
更新日期:1995-07-01 00:00:00
abstract::The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90263-5
更新日期:1995-06-01 00:00:00
abstract::The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90257-0
更新日期:1995-06-01 00:00:00
abstract::Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90340-2
更新日期:1995-05-01 00:00:00
abstract::Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprive...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90331-3
更新日期:1995-05-01 00:00:00
abstract::Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90211-2
更新日期:1995-04-01 00:00:00
abstract::Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90222-8
更新日期:1995-04-01 00:00:00
abstract::The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90310-0
更新日期:1995-03-01 00:00:00
abstract::Through specific intersubunit contacts, the four subunits of the nicotinic acetylcholine receptor assemble into an alpha 2 beta gamma delta pentamer. The specificity of subunit association leads to formation of proper ligand binding sites and to transport of assembled pentamers to the cell surface. To identify determi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90320-8
更新日期:1995-03-01 00:00:00
abstract::Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zinc superoxide dismutase protein (SOD) or with an expression vector co...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90287-2
更新日期:1995-02-01 00:00:00
abstract::Tau is abundant in the axon, whereas MAP2 is found in the cell body and dendrites. To understand their differential localization, we performed transfection studies on primary cultured neurons using tagged tau, MAP2, MAP2C, and their chimeric/deletion mutants. We found that MAP2 was prevented from entering the axon by ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90298-8
更新日期:1995-02-01 00:00:00
abstract::Terminal Schwann cells overlying the neuromuscular junction sprout elaborate processes upon muscle denervation. We show here that motor axons use these processes as guides/substrates during regeneration; in so doing, they escape the confines of endplates and grow between endplates to generate polyneuronal innervation....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90246-5
更新日期:1995-01-01 00:00:00
abstract::Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90239-2
更新日期:1995-01-01 00:00:00
abstract::Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90424-3
更新日期:1994-12-01 00:00:00
abstract::The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90051-5
更新日期:1994-11-01 00:00:00
abstract::The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90062-0
更新日期:1994-11-01 00:00:00
abstract::Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90257-7
更新日期:1994-10-01 00:00:00
abstract::Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90248-8
更新日期:1994-10-01 00:00:00
abstract::Neural circadian pacemakers can be reset by light, and the resetting mechanism may involve cyclic nucleotide second messengers. We have examined pacemaker resetting and free-running activity rhythms in Drosophila dunce (dnc) and DC0 mutants, which identify a cAMP specific phosphodiesterase and the catalytic subunit of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90262-3
更新日期:1994-10-01 00:00:00
abstract::The molecular mechanisms involved in glial/neuronal fate decisions during embryonic development are largely unknown. Here we show that the segment-polarity gene engrailed, which encodes a homeodomain protein, controls these decisions within an insect CNS lineage. The grasshopper median neuroblast (MNB) generates both ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90024-8
更新日期:1994-09-01 00:00:00
abstract::Simultaneous whole-cell recordings were made from the soma and dendrites of cerebellar Purkinje cells in rat brain slices. Sodium action potentials, evoked by either depolarizing current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with inc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90037-x
更新日期:1994-09-01 00:00:00
abstract::The differentiation of neuronal cell progenitors depends on complex interactions between intrinsic cellular programs and environmental cues. Such interactions have recently been explored using an immortalized sympathoadrenal progenitor cell line, MAH. These studies have revealed that depolarizing conditions, in combin...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90359-x
更新日期:1994-08-01 00:00:00
abstract::To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90458-8
更新日期:1994-07-01 00:00:00
abstract::Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90466-9
更新日期:1994-07-01 00:00:00
abstract::Many high threshold, voltage-gated Ca2+ channels, including the dihydropyridine-sensitive class (L-type), inactivate in response not only to voltage, but also to entry of Ca2+. Despite the physiological importance of this Ca(2+)-sensitive inactivation, its molecular mechanism is understood only in broad outline. We no...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90446-4
更新日期:1994-06-01 00:00:00